Spravato™ (Esketamine)
Innovative Healing with Spravato™ Nasal Spray
Spravato™ is a nasal spray that represents a breakthrough in the treatment of severe depression, offering rapid and effective relief when traditional antidepressants have failed.
A Beacon of Hope
At Cambridge Biotherapies™, we are committed to providing leading-edge treatments like Spravato™. Our team has seen firsthand the positive impact this therapy can have on patients struggling with severe and otherwise treatment-resistant depression.
Supportive Care Within a Structured Protocol
Spravato follows a strict FDA-regulated treatment protocol. While the dosing schedule itself is not customized, we tailor our support, monitoring, and guidance around each patient so they feel safe, informed, and cared for at every step.
An Affordable Treatment Option
For some people, IV Ketamine can be prohibitively expensive. While IV ketamine is covered by some insurance providers, Spravato™ is covered by most, which greatly improves affordability.
Begin Your Healing Journey
If you’re battling treatment-resistant depression, Spravato™ may be what makes the difference. Schedule a consultation with us to learn how this treatment can help you get back to feeling like yourself again.
Take the First Step Now
Spravato™ Treatment Near Me
Cambridge Biotherapies provides Spravato™ treatment across Massachusetts, including Springfield, Beverly, and our Cambridge treatment center, which caters to both Cambridge and Boston residents.
Each treatment center is staffed by a team of specialists trained in the effective and compassionate administration of Spravato™ therapy. Experience the benefits of this innovative treatment in a supportive and professional environment at a Cambridge Biotherapies treatment center near you.
Spravato™ in Springfield, MA
Our Springfield treatment center provides a serene setting for personal reflection and growth. Our experienced therapists are dedicated to supporting your journey to better mental health.
Spravato™ in Beverly, MA
Located in the heart of the North Shore, our Beverly center offers a tranquil environment for those seeking Spravato™ therapy. Our team is committed to guiding you through each step of your treatment with personalized care.
Spravato™ in Cambridge, MA
Our flagship center in Cambridge, also serving the Boston Metro area, integrates traditional and innovative treatments. This urban setting provides a vibrant backdrop for your healing journey, with comprehensive support from our skilled therapists.
Insurance and Cost Information for Spravato™
Spravato™ is covered by many insurance providers, making it a more affordable option for patients compared to some alternatives. Cambridge Biotherapies has built a detailed Insurance Coverage Page where you can review specific insurance providers and the treatments they cover, including Spravato™.
Out-of-Pocket Costs
For those without insurance or with limited mental health coverage, we provide transparent information about potential out-of-pocket costs. Options such as payment plans or financial consultations may be available to ease the financial burden.
Feel free to check our Insurance Coverage page for the latest details on accepted providers and coverage options for Spravato™.
Insurance Coverage
Many major insurance providers offer coverage for Spravato™ as part of mental health benefits.
Coverage varies by provider, so it’s essential to verify specific details. We work directly with you to confirm insurance eligibility and help you navigate the approval process.
What is Spravato™?
Spravato™ (esketamine) is a groundbreaking prescription nasal spray designed to treat adults with treatment-resistant depression. It is the first FDA-approved medication of its kind, offering a novel approach to mental health treatment. Unlike traditional antidepressants that primarily target serotonin, Spravato™ acts on the NMDA receptor in the brain, influencing glutamate, a neurotransmitter involved in mood regulation. This distinct mechanism of action helps alleviate depressive symptoms more rapidly and effectively for those who have not found relief with conventional therapies.
Spravato™ is now FDA-approved both as a standalone (monotherapy) treatment and as an adjunctive therapy alongside an oral antidepressant. This expanded approval allows for greater flexibility in tailoring treatment to each patient’s needs.
The treatment involves the patient self-administering the nasal spray under the supervision of a healthcare professional in a clinical setting. This ensures both safety and proper monitoring during the process.
The introduction of Spravato™ represents a significant advancement in the field of depression treatment, particularly for individuals who have struggled to find relief through other means. Its ability to work through a different pathway in the brain provides new hope and potential for rapid improvement in depressive symptoms.
At Cambridge Biotherapies, we are committed to offering innovative treatments like Spravato™ to help our patients achieve better mental health outcomes. Our experienced team is dedicated to providing the highest level of care and support throughout your treatment journey.
How Spravato™ Works
Spravato™ is administered under the careful supervision of our healthcare professionals at Cambridge Biotherapies treatment centers. Here’s what you can expect from the treatment process:
1. Preparation
Before starting Spravato™ therapy, patients undergo a thorough evaluation to determine eligibility and to set therapeutic goals. This involves an initial consultation where we discuss your medical history and current condition.
2. Administration
Spravato™ is a nasal spray that patients self-administer in our treatment center. The process is straightforward: patients use a nasal spray device to deliver the medication into their nostrils. Each session is supervised by our trained staff to ensure proper administration and immediate support if needed.
3. Monitoring
After administering Spravato™, patients are monitored for at least two hours. This monitoring period allows our healthcare team to ensure your safety and to observe any immediate effects of the medication. You will be in a comfortable, controlled environment designed to help you relax and experience the treatment’s full benefits.
Spravato™ Side Effects and Safety
At Cambridge Biotherapies, patient safety and comfort are our top priorities. Like all medications, Spravato™ may cause side effects. We provide medical supervision throughout each session to ensure a safe, supportive environment.
Common or Mild Side Effects
These side effects are typically mild and manageable and may subside during or after the session:
- Sleepiness: Patients may feel drowsy and require some rest.
- Nausea and Vomiting: This may occur shortly after administration and usually fades within the session’s monitoring period.
- Dissociation: Some patients experience a feeling of detachment from reality, which is closely monitored by our staff.
- Dizziness and Headache: These are common and often mild, but our team is ready to assist with any discomfort.
- Other Side Effects: Nose or throat irritation, altered taste, dry mouth, diarrhea or constipation, anxiety, increased heart rate, a feeling of intoxication, blurred vision, and numbness to touch.
Rare but Serious Side Effects
Rare but more serious side effects can occur, and our clinical team is prepared to respond if needed:
- High Blood Pressure: Monitoring helps manage blood pressure changes.
- Slowed Breathing: We watch for any signs of respiratory depression.
- Suicidal Thoughts and Behaviors: Although rare, this is closely monitored during and after treatment.
- Hallucinations and Loss of Consciousness: Experienced by some patients, requiring prompt intervention.
- Dependence and Misuse: Our controlled clinical environment and careful administration protocols reduce the risk of misuse.
Patients are observed for two hours after each session to ensure they respond safely to the treatment, and any immediate side effects are managed effectively.
Benefits of Spravato™
Spravato™ offers several key benefits, making it a valuable treatment option for individuals with treatment-resistant depression:
1. Rapid Symptom Relief
Unlike traditional antidepressants that can take weeks or months to show effects, Spravato™ can reduce depressive symptoms within hours to days. This rapid action can be crucial for patients experiencing severe depression.
2. Effective for Treatment-Resistant Depression
Spravato™ provides an alternative for those who have not responded to other treatments. Its unique mechanism of action, targeting the NMDA receptor and influencing glutamate levels, offers a new therapeutic pathway.
3. Enhanced Efficacy with Oral Antidepressants
When used in conjunction with an oral antidepressant, Spravato™ enhances overall treatment effectiveness, providing a comprehensive approach to managing depression.
(Spravato™ can now be prescribed on its own or in combination with an oral antidepressant, based on individual treatment plans.)
4. Supervised Administration for Safety
The administration of Spravato™ in our treatment centers under the supervision of healthcare professionals ensures a safe and controlled environment. This monitoring helps manage any immediate side effects and provides patients with the support they need during the treatment process.
5. Improved Quality of Life
By rapidly alleviating depressive symptoms, Spravato™ can significantly improve a patient’s quality of life, helping them return to daily activities and regain a sense of normalcy and well-being.
Who Is Eligible for Spravato™?
Spravato™ therapy is a treatment option for adults struggling with treatment-resistant depression and certain other mental health conditions. Eligibility for this groundbreaking therapy typically includes:
- Treatment-Resistant Depression: Spravato™ is intended for individuals who have tried at least two other antidepressant medications without significant improvement.
- Specific Conditions: Patients diagnosed with severe depressive disorders or other conditions that have not responded well to standard treatments.
- Customized Assessment: Each patient undergoes a thorough evaluation with our healthcare team to ensure Spravato™ is the right fit for their unique needs.
Note: Some medical conditions or medications may interact with Spravato™, making it unsuitable for certain patients. Schedule a consultation with our team to determine if Spravato™ is a viable option for your treatment plan.
Frequently Asked Questions About Spravato™
Our team is dedicated to making the Spravato™ treatment process as clear and supportive as possible. Here are answers to some of the most common questions about Spravato™:
What is Spravato™?
Who can benefit from Spravato™?
Treatment Process
How is Spravato™ administered?
How long is a Spravato™ session?
What does Spravato™ feel like?
How soon can I expect to see results?
Effectiveness
How quickly does Spravato™ work?
How often are treatments needed?
Insurance and Costs
Is Spravato™ covered by insurance?
Yes, Spravato™ is covered by most major insurers. Please visit our Insurance Coverage page for more information.
Safety and Side Effects
What are common side effects?
Logistics
Can I drive myself home after treatment?
Proven treatments for depression including
Ketamine Therapy, Spravato, and TMS that bring real relief.
Ketamine Infusions
Groundbreaking approach that has shown fast-acting relief for depression, anxiety, and more.
Spravato
Find rapid relief from depression with FDA-approved Esketamine (Spravato), covered by insurance.
Accelerated TMS / TMS Therapy
Cutting-edge medication-free therapy informed by published research on accelerated theta-burst stimulation protocols.
Psychedelic Therapy
Ketamine-Assisted Psychotherapy (KAP) combines preparation, medication (ketamine), and talk therapy.
It’s Time to Feel Better From Anxiety
We Meet
We hear your concerns, symptoms, and goals.
We Make a Plan
You’ll receive a personalized treatment plan from a licensed psychiatric professional.
We Begin
Your treatment will be overseen by our highly qualified medical staff. We’ll monitor and adjust the plan along the way as needed.
SPRAVATO® REMS: Safe Administration at Cambridge Biotherapies
Spravato™ (esketamine) is a groundbreaking treatment option for adults with treatment-resistant depression (TRD) and major depressive disorder (MDD) with acute suicidal ideation or behavior. Due to potential risks, Spravato™ is only available through a restricted program known as the SPRAVATO® REMS (Risk Evaluation and Mitigation Strategy).
Cambridge Biotherapies is Certified to Administer Spravato™
At Cambridge Biotherapies, we are fully certified under the SPRAVATO® REMS program to provide safe and effective Spravato™ treatment. Our healthcare professionals are equipped to handle all program requirements, including:
- In-Clinic Administration: Spravato™ is administered by our trained staff in a certified healthcare setting.
- Patient Monitoring: Patients are observed for two hours after treatment to ensure safety and comfort.
- Patient Enrollment: We manage the necessary REMS enrollment process for all patients.
How to Refer Your Patients for Spravato™ Therapy
If you have patients who may benefit from Spravato™, refer them to Cambridge Biotherapies for specialized care. We’ll take care of the REMS requirements and provide a safe, supportive environment for their treatment.
Refer a Patient Now to connect them with Spravato™ therapy at Cambridge Biotherapies.
Spravato™ Locations and Availability
Cambridge Biotherapies offers Spravato™ therapy at several convenient locations throughout Massachusetts. Each treatment center is staffed with compassionate, experienced professionals dedicated to providing the best care possible.
Our Treatment Centers
- Springfield, MA: Located in a peaceful setting, our Springfield center offers a serene environment to support your mental health journey.
- Beverly, MA: In the heart of the North Shore, our Beverly center provides a calming atmosphere for your treatment.
- Cambridge, MA: Our flagship center in Cambridge serves the Boston metro area, combining innovative treatments with compassionate care.
Each location has a highly trained team to administer and support Spravato™ therapy. Please Schedule a Consultation at the location most convenient for you to start your journey with us.


