It all started with ketamine. To some, vets mainly, it’s a horse tranquilizer. To others, a party drug. To those with severe clinical
depression, a potential, literal, life-saver. A dose of ketamine can
rapidly dull the symptoms of depression, providing immediate relief for those crippled by the darkest thoughts. And while ketamine does not work for everyone, it seems to work in many people who are untouched by standard
antidepressant drugs.
Ketamine could then be our best lead in the hunt for depression. For if we search for where ketamine affects the brain, and for how it affects the brain, we will get vital clues to the
cause of depression. And so to a long-lasting effective treatment. Two studies just published in
Nature used precisely this trick, and spectacularly uncovered not just
compelling evidence of the tiny brain region to target, but
exactly what goes wrong in it to create depression — that some neurons are, literally, depressed...