Diverging from conventional antidepressants, Ketamine offers swift respite from distressing ruminations such as shame, fear, and self-harm tendencies. By inhibiting a specific region in the brain known as the “anti-reward network,” it effectively silences the self-critical aspect, facilitating the disruption of entrenched patterns of thought and behavior that contribute to depression and anxiety.
Moreover, ketamine exhibits a remarkable capability to stimulate the brain, fortifying the connections between neurons that promote mental well-being. Strengthened neural pathways empower us to effectively manage intense emotions and effortlessly cultivate adaptive behavioral changes.
Ketamine exhibits a distinct mode of action compared to conventional antidepressants such as SSRIs. Unlike SSRIs, which often necessitate weeks or months to alleviate symptoms and frequently lead to undesirable side effects, ketamine operates differently. It does not linger in the body between treatments, thereby averting side effects such as sexual dysfunction or sleep disturbances. Instead, ketamine stimulates the brain to instigate natural neurological growth and connection, facilitating self-initiated changes.
The benefits of ketamine therapy can endure for weeks or even months for many individuals, while intermittent booster treatments can assist others in sustaining long-term benefits.
Ketamine engages with various facets of our psychology and physiology, although there is still much to comprehend regarding its mechanism of action. Research conducted in Boston, MA has indicated that the following factors significantly contribute to the therapeutic effects of ketamine.
Brain Regions and Chemicals to Know
A prominent neurotransmitter in the brain. Glutamate is now strongly associated with mood disorders. It is partly responsible for memory, learning, and mood regulation.
While this glutamate receptor and ion channel has many different roles, researchers have implicated it in mental health issues. Overactive NMDArs are associated with heightened depression and general distress.
This receptor is suspected to be primarily responsible for instigating neural plasticity in excitatory transmission. It is a key region of stimulation regarding ketamine’s healing properties.
Brain-derived neurotrophic factor signals new neural growth in the brain and is released when glutamate stimulates the AMPA receptor.
The mammalian target of rapamycin complex 1 (mTOR) is a signaling pathway that regulates new neural growth. Its stimulation is associated with the effects of BDNF.
The lateral habenula is a brain region largely responsible for our interpreting and predicting negative consequences. Those with depression and anxiety show an overactivity of burst firing in the lateral habenula.
Ketamine functions as a non-competitive antagonist of the NMDA receptor, preventing the activation of the receptor by glutamate. Recent evidence suggests that ketamine has inhibitory effects specifically on the NMDA receptor in the lateral habenula, a brain region primarily involved in encoding negative or anti-reward associations. Individuals with depression and anxiety often exhibit excessive burst firing activity in the lateral habenula.
The inhibition of the NMDA receptor by ketamine can lead to an accumulation of free glutamate, which then triggers the activation of AMPA receptors. Increased AMPA receptor activity is associated with the release of brain-derived neurotrophic factor (BDNF), a chemical that plays a significant role in promoting the growth of new neural connections. This neuroplasticity may redirect brain activity away from hyperactive regions linked to negative reward signals, ultimately providing long-term relief from mental health conditions. Contact Cambride Biotherapies today and leanr how our ketamine treatment program can help you on your path to healing.
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Verify no eating in prior 2 hrs + no liquids in prior 30 min
Set Up & Medicine Administration (20 Min)
Get settled in treatment room
Review Plan for the Session, Q&A
Intention Setting / Re-presencing
Get Comfortable, Apply Eye Shades & Start Curated Music
Infusion starts and continues for 40 minutes
10-30 min + sitting, talking with infusion nurse, or listening to music, journaling or meditating
Herbal Tea, Water Available
No Driving or Operating Heavy Machinery
Medically cleared prior to departure